How many cpu 's do you have on your machine.set the db_block_lru_latches to approximately twice the number of cpus if your instance is hevaily loaded.say for example if u have 10 cpus i suggest that you first start out with something like 5 then check for latch contenation with V$LATCH,V$SESSION_EVENT
Note however if you have a single cpu machine you wont greatly benifit by setting this paarmeter.
We are running oracle on active-pasive clustering on NT 4.0. The memory for the each nodes is 1.2 GB. Currently we havedb_block_buffers = 1550
db_block_lru_latches = 31.
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